Bioinformatics is a well-established discipline with universally recognized and required skills on the national and international market, in both the public and private sector. This discipline historically developed from the sequencing of the genomes of model organisms and above all of the human genome in the 1990s and has now become included in basic research in genetics, biochemistry, and molecular biology and in the more applicative biomedical field to the point a close peer-to-peer collaboration is required between the biologist/ medic and the expert in data analysis (bioinformatics).
The course mainly deals with:
- Providing mathematical-statistical models that can be used in the analysis and interpretation of experimental biomolecular data. The most important aspect regards the need to integrate enormous quantities of data (big data) coming from extremely heterogeneous sources ("omics" technologies) to identify the "key" elements at the base of a specific biological process which is of interest to the medic/biologist.
- Developing computational models and methods for the analysis of biological sequences and gene expression data (genome, transcriptome, proteome, epigenetic profiles, post-transcriptional and post-translational modifications, genomic protein localization, genetic polymorphisms, RNA / DNA editing, etc.) in order to identify phylogenetic specificities/similarities and relevant mutations, which can be used, for example, in diagnosis and personalized medical therapies (tumors, vaccines, genetic diseases).
- Organizing integrated archives equipped with analysis platforms for better use and presentation of biomolecular data
- Analyzing and predicting the structural and functional aspects of macromolecules and their interactions with ligands and drugs.
In this regard, a "new alliance" between bioengineering (bioinformatics), biology, chemistry, and medicine appears to be of great strategic importance in order to respond to the challenges arising due to the overwhelming development of biomolecular technologies.
About the School
With over 700 years of history, 113,500 students, 3,300 teachers and 2,000 employees, technicians and librarians, in addition to 1,800 administrative staff in university hospitals, Sapienza is the fir ... Read More